API

Peptides

Along with proteins, peptide delivery has an increasingly important role in new drug development. Challenges in peptide formulation are, amongst others, short in-vivo half-life due to rapid enzymatic degradation. InnoCore’s sustained release technologies are capable of releasing peptides structurally intact over a period of time, ranging from days to several weeks.

The top ten benefits of our sustained release technologies for peptides:

• Several formulation possibilities, including microspheres, gels, coatings and implants

• High encapsulation efficiency (in average higher than 80%)

• Protection from environmental influences, like proteases

• Release in a controlled manner by diffusion which can be tuned by variation of the SynBiosys® or InGell® building blocks ratio resulting in limited or no burst

• Protection from increased temperature (during processing and storage)

• Loadings varying from 20-50% (depending on size and solubility)

• Multi-block polymeric architectures offering endless possibilities for fine tuning of properties

• Optimal control over the physicochemical and degradation characteristics

• Protection from high shear forces during processing

• No accumulation of acidic degradation products, allowing peptides to remain structurally intact

 

Read more about our polymer platform SynBiosys® and Ingell®