There are more advantages to sustained release, exceeding the clinic:
Administering drugs to hard-to-reach areas, such as intraarticular space, the heart, or the eye, is extremely inconvenient to patients, especially in case of recurring injections. It can even bring patients to stop or refuse the treatment. Sustained-release drugs significantly lower the injection frequency. As a result, patient convenience and treatment compliance improves. Moreover, locally administered long-acting injectables, e.g. intratumoral administration, increase the efficacy and limit the side effects of potent drugs, further improving patient compliance.