Our Solutions

Compounds

Peptides


Along with proteins, peptides have an increasingly important role in new drug development. Challenges in peptide formulation are, amongst others, short in-vivo half-life because of rapid enzymatic degradation.

 

InnoCore’s sustained release technologies are capable of releasing peptides structurally intact over a period of time, ranging from days to several weeks.

 

The top ten benefits of our sustained release technologies for peptides:

  1. Several formulation possibilities, including microspheres, gels, coatings and implants
  2. High encapsulation efficiency (in average higher than 80%)
  3. Protection from environmental influences, like proteases
  4. Release in a controlled manner by diffusion which can be tuned by variation of the SynBiosys® or InGell® building blocks ratio resulting in limited or no burst
  5. Protection from increased temperature (during processing and storage
  6. Loadings varying from 20-50% (depending on size and solubility)
  7. Multi-block polymeric architectures that offers endless possibilities for fine tuning of properties
  8. Optimal control over the physico-chemical and degradation characteristics: for our biodegradable polymers, a rule of thumb for 1-month sustained delivery formulation, the polymers will be cleared in not more than two months.
  9. Protection from high shear forces during processing
  10. No accumulation of acidic degradation products, allowing peptides to remain structurally intact

 

Read more about our technologies SynBiosys and Ingell here.

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