Sustained release

In today's health care industry, sustained drug delivery has become key in pharmaceutical product development. Innovative sustained release technologies allow for increased performance of new and existing pharmaceutical compounds. Patients benefit from the enhanced efficacy of pharmaceutical products and from reduction of side-effects. Clinical advantages include:

 

Controlling the release curves by adjusting the polymer composition with Bovine Serum Albumin

 

  • Longer duration of action by sustained release of the drug
  • Lower plasma levels with less toxic and less systemic exposure, leading to a reduction of side effects.
  • Reduced injection frequency
  • Improved patient compliance because of a more convenient user experience
  • Enhanced therapeutic efficacy

Inactivation of proteins by aggregation or denaturation

 

 

There are more advantages to sustained release, exceeding the clinic:

  • Improved stability by encapsulating the compound in a polymer matrix, thus protecting it from environmental influences.
  • A sustained release formulation can be a solution for insoluble compounds.
  • More cost effective due to lower dosing levels and drug usage
  • Opportunity to develop formulations for insoluble compounds
  • Easier storage and transport
  • Life cycle management
  • Possibility for new therapies

 

 

Hard to reach areas

An example of benificial use of a sustained release technology: Hard-to-reach areas

Administering drugs to hard-to-reach areas such as joints, the heart or the eye, is extremely inconvenient to patients, especially in case of recurring injections. It can even bring patients to stop or refuse the treatment. Sustained release drugs significantly lower the injection frequency. As a result, patient convenience and treatment compliance improve.